They are transcribed by RNA polymerase II, and most of their functions are not entirely understood.5 Long noncoding RNAs are involved in the epigenetic, transcriptional, and post-transcriptional stages and play a role in the etiology and pathophysiology of many cancers.5-7 Overexpression of LncRNAs from HOTAIR, MALAT1, H19, and XIST genes leads to upregulation of genes that have a critical role in the tumor process such as oncogenes involved in the MYC or WNT signaling pathway.8 The gene discussed is HOTAIR; the disease is cancer.