STAT3 and neoplasm: Several inflammation–carcinogenesis-related signaling pathways, such as IL-6/JAK/STAT3, have been proven to involve in the progression of inflammation, epithelial–mesenchymal transition/cell transformation, and malignancy.41 Kusaba et al42 found that the content of p-STAT3 increased significantly in CRC tissue, and phosphorylated STAT3 (p-STAT3) had a certain impact on tumor growth, metastasis, and invasion.