Our study detected the cell proliferation-related protein PCNA and core protein p-STAT3 in the STAT3 signaling pathway to explore the pathogenic process of colonic tissue from normal mucosa to inflammatory mucosa to atypical hyperplasia to carcinogenesis, so as to explore the dynamic change rate of JAK/STAT pathway in the process of inflammation to tumor. This evidence concerns the gene STAT3 and neoplasm.