It is reported that IL-6 transduction signal can increase the phosphorylation of STAT3 in tumor cells, which is considered to be a key anti-apoptotic regulator in colitis-related CRC.43,44 Our findings showed that p-STAT3 expression was significantly increased in mice of the UC model group compared with that in mice of the control group. The gene discussed is IL6; the disease is colorectal carcinoma.