In a study by Amiot et al.11 on 294 patients with anti-TNF refractory IBD, steroid-free remission was found in 31% and response to treatment in 50% of Crohn’s disease patients at 14 weeks, whereas, steroid-free remission was found in 36% and response to treatment in 50% of patients with UC. The gene discussed is TNF; the disease is Crohn disease.