To test this hypothesis, we established an in vitro co-culture system that consisted of the neuroblastoma-derived human cell line SH-SY5Y, which displays catecholaminergic neuronal properties (Xicoy et al., 2017), and primary meningeal cells derived from wild-type and Col6a1–/– pups, and compared the properties of these co-cultures with those of SH-SY5Y cells cultured alone in the absence of other cell types. This evidence concerns the gene COL6A1 and neuroblastoma.