TF and nutritional disorder: Nevertheless, many RLS patients do not show systemic iron deficiency but rather appear to have a specific iron deficiency in the brain, substantiated by relatively lower CSF ferritin, higher CSF transferrin and reduced CSF ferritin/plasma ferritin levels compared to those of controls (Earley et al., 2000; Mizuno et al., 2005), as well as decreased iron content of the SN, striatum, pallidal complex and thalamus (Allen et al., 2001; Godau et al., 2007, 2008; Rizzo et al., 2013; Li et al., 2016).