Cytoskeletal dynamics are further implicated in the pathogenesis of ALS/FTD by disease-causing mutations in DCTN1 (Münch et al., 2005), PFN1 (Wu et al., 2012; Smith et al., 2015) and TUBA4A (Smith et al., 2014). Here, TUBA4A is linked to amyotrophic lateral sclerosis.