TARDBP and amyotrophic lateral sclerosis: Depleting TDP-43 is gaining acceptance in a field initially predominated by overexpression and TDP-43-mutant models (Wegorzewska and Baloh, 2011; Liu et al., 2013), and here we demonstrate that TDP-43 depletion recapitulates at least some of the transcriptional effects of loss of nuclear TDP-43 in ALS/FTD neuronal nuclei.