NLRP5 and infertility disorder: To date, five studies have focused on 13 variants (Figure 2b) and demonstrated that NLRP5 mutations are responsible for oocyte maturation dysfunction, fertility disorder, and EEA (Huang et al., 2022; M. Li et al., 2021; Mu et al., 2019; Xu et al., 2020; W. Zheng et al., 2021).