Several studies have demonstrated that mutations in SCMC‐related genes (TLE6, PADI6, NLRP2, NLRP5, and KHDC3L) cause human female infertility in the form of an exhibition of EEA and fragmentation (Maddirevula et al., 2017; Mu et al., 2019; Wang et al., 2018; Xu et al., 2016). The gene discussed is NLRP5; the disease is female infertility.