MAPT and Alzheimer disease: TRIM28 has been shown to promote α-syn and tau proteins accumulation in the nucleus via its E3 ubiquitin ligase activity, resulting in the pathogenesis of PD or AD [88].TRIM28 regulates the pathogenic stage of α-syn and tau proteins post-translationally, and any slight decrease in TRIM28 abundance can lead to a decrease in both α-syn and tau protein aggregates.