For example, TRIM11 can facilitate the degradation of defective proteins such as Atxn1 [82Q]—a pathogenic protein that causes spinocerebellar ataxia type1 (SCA1)—in the nucleus and cytoplasm in familial NDs via the proteasome [33,38]. The gene discussed is ATXN1; the disease is spinocerebellar ataxia type 1.