Among the genes regulatable by at least 2 of the signals, several are involved in the regulation of fat mass and obesity, that is, in either lipid metabolism (AGPAT2, FADS2, LDLR, PDK4, SCD and TXNRD1), extracellular matrix (FN1, SERPINE1), stress and/or inflammation (AKR1B1, C1S, CTSC) (Table S6). This evidence concerns the gene CTSC and obesity due to melanocortin 4 receptor deficiency.