Among the genes regulatable by at least 2 of the signals, several are involved in the regulation of fat mass and obesity, that is, in either lipid metabolism (AGPAT2, FADS2, LDLR, PDK4, SCD and TXNRD1), extracellular matrix (FN1, SERPINE1), stress and/or inflammation (AKR1B1, C1S, CTSC) (Table S6). The gene discussed is SERPINE1; the disease is obesity disorder.