REG4 and Familial prostate cancer: In cancer cells, overexpression of REG IV gene was also reported in colorectal carcinoma,26, 27, 28, 29, 30 gastric cancer,31, 32, 33, 34 gallbladder carcinoma,35, 36 prostate cancer,37, 38 pancreatic cancer,39, 40, 41 glioma42 and ovarian carcinoma.43, 44, 45