In cancer cells, overexpression of REG IV gene was also reported in colorectal carcinoma,26, 27, 28, 29, 30 gastric cancer,31, 32, 33, 34 gallbladder carcinoma,35, 36 prostate cancer,37, 38 pancreatic cancer,39, 40, 41 glioma42 and ovarian carcinoma.43, 44, 45. This evidence concerns the gene REG4 and colorectal carcinoma.