In cancer cells, overexpression of REG IV gene was also reported in colorectal carcinoma,26, 27, 28, 29, 30 gastric cancer,31, 32, 33, 34 gallbladder carcinoma,35, 36 prostate cancer,37, 38 pancreatic cancer,39, 40, 41 glioma42 and ovarian carcinoma.43, 44, 45. Here, REG4 is linked to familial pancreatic carcinoma.