Hottz et al. (2013) found NLRP3 inflammasome was activated to release increased interleukin-1β (IL-1β) in activated platelets, with increased expression of P-selectin (CD62P), which is associated with thrombocytopenia in patients with dengue fever. IL-1β, an important inflammatory factor mediated by NLRP3-dependent caspase-1 activation, is linked to increased endothelial permeability (Bozza et al., 2008), thrombosis, and dysregulated hemostasis in dengue fever (Qiao et al., 2018). What’s more, significantly increased IL-1β levels have been found in HS (Geng et al., 2015). Here, NLRP3 is linked to dengue disease.