Many evidence identified a link bewteen alterations found in the calcium voltage-gated channel subunit alpha 1 (CACNA1A; OMIM#601011) and in the glutamate transporter excitatory amino acid transporter 1 (SLC1A3; OMIM#600111) with the impaired neurotransmitter release in a wide range of neurodevelopmental disorders, among which are episodic ataxia, type 2 (OMIM#108500); migraine, familial hemiplegic, 1 (OMIM#141500); and spinocerebellar atxia 6 (OMIM#183086).[54,55]. Here, SLC1A3 is linked to episodic ataxia type 2.