Three children with features resembling those reported by Panagiotakaki et al.[6] were described by Marzin et al.[73] as presenting de novo p.Asp742Tyr, p.Cys346Arg, and p.Asp609Tyr, respectively sequence variants in ATP1A3. All 3 children showed early-onset epilepsy, movement disorders unrelated to epilepsy, and severe DD. Here, ATP1A3 is linked to epilepsy.