ATP1A3 and Apnea: Two girls, one with a p.Gly89fs carrier in ATP1A3 mutations and the other with a p.Gly706Arg ATP1A3 variant, were reported by Holze et al.[74]: the girls complained since the first year of life of severe episodes of apnea that the authors maintained as early-onset autonomic seizures related to the underlying pathogenetic ATP1A3 variants.