Mutations in ATP1A2 (AHC1; OMIM#104290) and ATP1A3 (AHC2; OMIM#614820), which encode two different alpha subunits of the neuronal NA+-K+ ATPase transmembrane ion pump, are the most frequent involved genes.[7–10] AHC individuals with ATP1A3 mutations are numerically more common than those with ATP1A2 mutations.[11] The wider use of genetic technology has enabled it to differentiate AHC diagnosis from other similar disorders and to extend its clinical spectrum. The gene discussed is ATP1A2; the disease is alternating hemiplegia of childhood.