GRN and myalgic encephalomeyelitis/chronic fatigue syndrome: Moxibustion may affect CFS by up-regulating the expression of Progranulin (PGRN) in the hippocampus.[87] The role of PGRN in the hippocampus includes neurotrophic effects,[88] regulation of neurogenesis, protection of nerves[89] and inhibition of inflammation.[90] PGRN is a key regulator of inflammation.