Lidia Karabon and Anna Partyka found that SNP in the BTLA rs1982809 was an increased risk factor for chronic lymphocytic leukemia (CLL) and renal cell carcinoma (RCC) in the Polish people.[18,19] Tang et al. reported that rs1982809 polymorphism was proved to be correlated with Esophagogastric junction adenocarcinoma (EGJA) in smoking patients.[20] This SNP is not associated with Esophageal squamous cell carcinoma (ESCC) in Chinese in the study of Cao et al.,[14] and the latest study in Tunisia showed that BTLA rs1982809 might cause lung cancer (LC)[21]. The gene discussed is BTLA; the disease is B-cell chronic lymphocytic leukemia.