TMEM158 and rectal cancer: For example, HOXB7 is highly expressed in breast cancer, ovarian cancer, and melanoma samples.[42–45] STC2 is highly expressed in rectal cancer and colon cancer.[46,47] TMEM158 is upregulated in laryngeal cancer, glioblastoma, and colorectal cancer.[48–50] TUBB3 is upregulated in gastric cancer, gallbladder cancer, and ovarian cancer.[51–53] STC2 is the encoding gene for stanniocalcin-2.