THRSP and breast cancer: And the increased expression of THRSP predicted tumor recurrence and poor prognosis for patients with breast cancer.[16,17] Besides, the elevated THRSP expression exerts a critical role in the pathogenesis of liver-related diseases by regulating lipid metabolism.[18,19] The study of Hu et al proved that the reduced expression of THRSP in hepatocellular carcinoma had a positive relationship with a more aggressive phenotype, larger tumor size, and recurrence.[20] In recent years, some genes have been proved to be crucial in the pathogenesis of THCA.