THRSP and cancer: Abnormal mRNA expression of THRSP was observed in breast cancer, kidney cancer, and liver cancer.[25,26] We found that THRSP was lowly expressed in 12 kinds of tumor tissues, but highly expressed in THCA and KICH, which might result from the heterogeneity of cancer.[27] In addition, the differential expression pattern is possibly due to the different epigenetic status of THRSP.[28] Compared with adjacent normal tissues, THRSP mRNA expression was significantly higher in THCA tissues.