ZEB1 and hepatocellular carcinoma: Notably, THRSP suppressed the hepatocellular carcinoma cell proliferation, migration, and invasion by inhibiting the ERK/ZEB1 pathway induced by the EMT process.[20,29] Moreover, THRSP overexpression in the MMTV-Neu transgenic model reduced mammary tumor metastasis compared to controls.[30] The authors speculated that THRSP might inhibit THCA cell proliferation, migration, and invasion via inhibition of the EMT process; hence, the THCA patients with higher THRSP expression tended to have better clinical outcomes.