LNM had a close correlation with an unfavorable prognosis of thyroid cancer.[7] Some clinical characteristics such as age, gender, and tumor size were identified as biomarkers for predicting LNM, but their functions are limited.[34] Besides, the alterations of genes including BRAF and TERT have been proved to be associated with LNM, but with contradictory results.[35–38] In this study, the increased expression level of THRSP was significantly related to low LNM risk through logistic regression analysis. This evidence concerns the gene THRSP and thyroid cancer.