THRSP and metastatic malignant neoplasm in the lymph nodes: Wells et al presented that low THRSP expression prolonged DFS of invasive breast cancer patients, but its expression did not differ between invasive cancers with or without lymph node metastases.[15] Interestingly, we found that THRSP was significantly higher in THCA patients at the N0 stage than that at the N1 stage, indicating that THCA patients with high THRSP expression are less likely to develop lymph node metastases.