In conclusion, HSC should be highly vigilant when the liver mass has the following characteristics: (1) The tumor index AFP is in the normal range, the density/signal in the CT/MRI scan is uneven, the enhancement is progressive or persistent, and the central necrosis is (2) with adjacent bile duct dilatation, multiple intrahepatic metastases, lymphadenopathy, vascular invasion or intratumoral hemorrhage; (3) lobulated, marginal arterial phase enhancement, peripheral washout, central delayed enhancement. The gene discussed is AFP; the disease is neoplasm.