Recent studies showed that METTL3-mediated m6A hypermethylation promotes the progression of bladder cancer by regulating SETD7/KLF4 mRNA expression [271], pri-mrR221/222 maturation [37] and AFE4/NF-κB/MYC signaling network activation [272]. The gene discussed is KLF4; the disease is urinary bladder carcinoma.