Recent studies showed that METTL3-mediated m6A hypermethylation promotes the progression of bladder cancer by regulating SETD7/KLF4 mRNA expression [271], pri-mrR221/222 maturation [37] and AFE4/NF-κB/MYC signaling network activation [272]. Here, METTL3 is linked to urinary bladder carcinoma.