Of these, we excluded 8853/62,419 Medicaid Aid beneficiaries, 22,745/53,566 with RA treatment history, 1388/30,821 with cancer history during the screening period, 532/29,433 younger than 19 years, 2351/28,901 treated with non-TNF biologics, and then 3699/26,550 treated with TNF inhibitors or nbDMARDs for less than 6 months or with poor compliance with TNF inhibitor use. The gene discussed is TNF; the disease is rheumatoid arthritis.