To further explore the impact of LINC00520 on TMZ resistance of GBM in vitro, U251/TMZ and SKMG-1/TMZ cells were transfected with siRNA for LINC00520, and cells in the control group were transfected with siRNA empty vector (P < 0.001)(Fig. 1C). Here, LINC00520 is linked to glioblastoma.