In a study by McClellan et al. [140] it was reported that treadmill running for 1 h/day and 6 days a week at 15 m/min resulted in the decreased expression levels of specific markers for macrophage (IL-12, IL-23 and Nos2, CD206, IL-10, IL-4, CCL17, CCL22, and Arg-1) and T-cells (CD8 and Foxp3), hence led to reduced CRC progression. The gene discussed is NOS2; the disease is colorectal carcinoma.