For example, in GUSTO, a randomized controlled trial in patients with myocardial infarction, the most effective thrombolytic regimen was accelerated tPA in a bolus of 15 mg, 0.75 mg/kg in 30 min, not to exceed 50 mg, and 0.5 mg/kg, up to 35 mg, over the next 60 min combined with intravenous heparin. The gene discussed is PLAT; the disease is myocardial infarction.