Preliminary results in the expansion part of this Phase 1 study showed the activity of E7090 with an overall response rate (ORR) of 83.3% (5/6) and 11.1% (1/9) in patients with cholangiocarcinoma harboring an FGFR2 gene fusion and in those with gastric cancer harboring either FGFR2 gene amplification or FGFR2 protein high expression, respectively. This evidence concerns the gene FGFR2 and gastric cancer.