More importantly, as a ubiquitous feature of solid tumors, hypoxia exhibits a positive correlation with EMT-induced cisplatin refractoriness via the PI3K/Akt/HIF-1α pathway, such that suppression of the aforementioned axis will undoubtedly enhance the therapeutic outcomes of hypoxic chemotherapy in HCC [46]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.