EPAS1 and hepatocellular carcinoma: Finally, lncRNA-MALAT1 induced by HIF-2α is upregulated in 5-FU-resistant Bel-7402 cells, and transfection of MALAT1 siRNA or miR-216b mimics leads to reduced LC3-II levels and increased p62 accumulation, implying the significance of the HIF-2α/MALAT1/miR-216b axis in autophagy-related chemoresistance of HCC [77].