However, no published study has discussed the MRI combining with clinical pathological risk factors, such as Ki-67 index, histological grade, and lymph node metastasis, in predicting HER2 expression, and no published study has applied clinicoradiomic models (nomogram) using multiple machine learning algorithms in predicting HER2 expression in invasive ductal carcinoma. This evidence concerns the gene ERBB2 and invasive ductal breast carcinoma.