The five most significant tumor data of each member of the EFNA family and methylation correlation were shown in Supplementary Fig. 2B. The methylation difference between tumor and normal samples was summarized in Fig. 3D. EFNA1 had higher methylation in LUSC, whereas EFNA5 had higher methylation in COAD, KIRP, PRAD, and THCA. The gene discussed is EFNA1; the disease is neoplasm.