Periodontal disease is caused by a bacterial infection that activates the innate immune response via Toll-like receptors, resulting in the up-regulation of innate immunity cytokines such as Tumor Necrosis Factor-α(TNF-α), Interleukin-1(IL-1), and Interleukin-6(IL-6) to ultimately cause progressive tissue destruction [7]. This evidence concerns the gene TNF and periodontal disorder.