HYAL3 and bladder transitional cell carcinoma: However, when the associations between HYAL3 expression and clinicopathological parameters in BLCA patients were compared, we found that the HYAL3 mRNA expression levels were higher in those aged > 70 years old and in those who died compared with the other patients (P = 0.02 and 0.04, respectively; Fig. 4a–b).