Furthermore, mice without ALDH1A1 are resistant to diet-induced obesity, and inhibition of ALDH1A1 in mice suppresses weight gain [27, 28], which is consistent with our finding and illustrates the potential for ALDH1A1 as a drug target for obesity prevention or treatment. The gene discussed is ALDH1A1; the disease is obesity due to melanocortin 4 receptor deficiency.