TP53 and central nervous system cancer: There were also individual gliomas that clustered with pleomorphic xanthoastrocytoma (which had co-occurring BRAF p.V600E mutation and CDKN2A homozygous deletion) and H3 K27-altered diffuse midline glioma (which had co-occurring SUZ12 deletion, TP53 mutation, and ATRX mutation) (Supplementary Fig. 7 [Online Resource 2]).