Intriguingly, we have identified that our cohort of NF1-associated low-grade gliomas resolve into a single epigenetic cluster, despite occurring at different anatomic sites and having variable histologic features ranging from conventional pilocytic astrocytoma to those with an infiltrative growth pattern resembling diffuse astrocytoma or with a ganglion cell component resembling ganglioglioma. This evidence concerns the gene NF1 and central nervous system cancer.