The 14 NF1-associated gliomas belonging to the molecular high-grade group did not form a distinct epigenomic cluster but instead aligned with other sporadic reference entities, most frequently high-grade astrocytoma with piloid features (HGAP, 36%) and various subclasses of IDH-wildtype glioblastoma (43%) (Fig. 5, Supplementary Fig. 4 [Online Resource 2], Supplementary Table 10 [Online Resource 1]). Here, NF1 is linked to central nervous system cancer.