Kaplan–Meier survival analysis revealed inferior outcomes for those patients with NF1-associated gliomas epigenetically aligning with HGAP or IDH-wildtype glioblastoma compared to those aligning with the novel NF1-associated pilocytic astrocytoma group (Supplementary Fig. 8 [Online Resource 2]). This evidence concerns the gene NF1 and pilocytic astrocytoma.