PURA and esophageal squamous cell carcinoma: It was observed that G3BP1 is localized in PURα-positive granules and that the number of PURα/G3BP1-positive granules under stress conditions markedly increased compared with those under native conditions, while the number of G3BP1-positive granules markedly decreased after the loss of PURα (Fig. 1B, C), demonstrating that cytoplasmic PURα in ESCC cells participates in the formation of stress granules.