Based on the inhibitory effect of PURα on the protein expression of IGFBP3 in the cytoplasm and the regulation of IGFBP3 during the progression of several types of tumors [45–47], IGFBP3 was selected as a downstream mRNA target to investigate whether cytoplasmic PURα effects on ESCC progression. Here, IGFBP3 is linked to esophageal squamous cell carcinoma.