Researchers reported that DPP4 is responsible for degradation of B-type natriuretic peptide (BNP), stromal cell–derived factor 1α (SDF-1α), and substance P. Gliptins effectively mitigate the deleterious effects of postprandial hyperglycemia on oxidative stress, inflammation, and CV remodeling. This evidence concerns the gene TAC1 and Hyperglycemia.