We found that IL-1 β and TNF-α levels in the hippocampus and peripheral serum increased at 24 h following intestinal ischemia/reperfusion injury; additionally, the number of crossings of the target platform and the time spent in the target quadrant both decreased in mice in the I/R group that underwent the MWM test, thus confirming that intestinal I/R injury could aggravate CNS inflammation and lead to cognitive dysfunction. This evidence concerns the gene TNF and ischemia.