TH and ischemia: To evaluate whether dexmedetomidine improved neuroinflammation and cognitive function through the LCNE system after intestinal ischemia/reperfusion injury in mice, we used the neurotoxic drug DSP-4 to selectively degrade LC norepinephrine neurons at 2 weeks and 1 week before operation, which was confirmed by immunofluorescence staining showing a significant decrease in TH-positive neurons in the LC.