SOX2 and cancer: There is a consensus that SOX2 expression increases during the development of cervical cancer (Liu et al. 2014; Stewart and Crook 2016; Kim et al. 2015; Chang et al. 2015; Moshi et al. 2020), but in high-grade lesions SOX2 expression is not always found throughout the full thickness of the epithelium, while microinvasive cancer cells adjacent to CIN3 have been reported to be negative Stewart and Crook 2016.