Among the 12 proteins with the strongest association with HF, 11 were associated with increased risk of HF: TNFRSF10A, ST6GAL1, PRCP, MMP12, TIMP1, CCL3, QPCT, ANG, C1QTNF1, SERPINA5 and GAL-9; and one was related to reduced risk of HF: LPL (see Supplementary Table 1 for the full names of these proteins). This evidence concerns the gene MMP12 and hydrops fetalis.