Our mechanistic study shows that GFAT1 along with TAB1 S438 phosphorylation contributes to p38 MAPK activation, thus we performed IHC analyses in serial sections of 87 human lung adenocarcinoma specimens to examine the clinical relevance of GFAT1, p-p38 level and TAB1 S438 phosphorylation levels (Fig. 6c). This evidence concerns the gene MAPK14 and lung adenocarcinoma.