Here, we found that GFAT1 facilitates TAB1-coupled p38 MAPK activation and contributes to lung adenocarcinoma cell survival under glucose deficiency through its positive effect on autophagy occurrence, pointing out GFAT1 could be a potential therapeutic target against lung adenocarcinoma. The gene discussed is GFPT1; the disease is hyperinsulinemic hypoglycemia, familial, 4.