The authors showed that macrophage-derived APOE, through its binding to LDL receptor (LDLR) and activation of NF-κB signaling, activates Cxcl1 and Cxcl5 production in PDAC cells, which drive the recruitment of myeloid cells and the suppression of tumor-infiltrating CD8+ T cells [92]. Here, LDLR is linked to neoplasm.