As an example, increased 27-hydroxycholesterol (HC) levels, induced by cholesterol-enriched diet in positive or negative estrogen receptor α mouse mammary cancer models, favor tumor recruitment of immunosuppressive cells (i.e., polymorphonuclear-neutrophils and γδ-T cells) at the expense of cytotoxic CD8+ T cell depletion [69]. Here, CD8A is linked to neoplasm.