In a recent study published in Science, Bridget S. Gosis et al. demonstrate that selective inhibition of the mammalian target of rapamycin complex 1 (mTORC1) signaling through deletion of the RagC/D guanosine triphosphatase-activating protein folliculin (FLCN) in mice enhances activation of transcription factor E3 (TFE3) in the liver and protects against nonalcoholic fatty liver disease (NAFLD).1 Here, TFE3 is linked to metabolic dysfunction-associated steatotic liver disease.