KEAP1 and head and neck squamous cell carcinoma: Congruent with this finding, our results report a role in chemoresistance on HNSCC cells which is mediated through increased Notch signaling and increased Notch pathway components upon Nrf2 activation in Keap1 mutated cells, suggesting that Notch also plays a role in mediating the effects of Nrf2 activation in HNSCC cells.