C4B and early-onset autosomal dominant Alzheimer disease: Starting at month-6, this upregulated protein set includes neuroinflammatory-related proteins like complement C4-B, glial fibrillary acidic protein, protein-arginine deiminase type-2, vimentin, and vitronectin that have long been associated with Alzheimer’s disease (21, 38, 39, 40, 41, 42) (supplemental Table S5).