APP and Alzheimer disease: Specifically, APP’s fold change (X ̄5XFAD/X ̄WT) as time progresses goes from 2.73 at 3 months to 3.50 at 6 months and 5.59 at 9 months revealing a temporal accumulation of both APP and Aβ in 5XFAD mice which mimics the increased amyloid burden characteristic of human AD.