APOE and Alzheimer disease: Our highly upregulated protein list (supplemental Table S5) includes known AD biomarkers when matched with DisGeNET’s AD biomarker database (CUI: C002395), including Aβ precursor protein, apolipoprotein E (29, 45), glial fibrillary acidic protein (30), serine protease HTRA1, mesencephalic astrocyte-derived neurotrophic factor, protein-arginine deiminase type-2 (40), and integral membrane protein 2B.