Moreover, we matched our sex-specific protein list (supplemental Table S4) against DisGeNET’s AD biomarker database (CUI: C002395) and we found six novel AD-associated proteins (AFG32, ATX10, CSN8, KIF2C, ROGDI, VPS11); of these, only CSN8 and ROGDI are upregulated in males (Table 1). The gene discussed is COPS8; the disease is Alzheimer disease.