Furthermore, the cell-intrinsic signaling of PD-L1 preserves tumor cells from interferon (IFN) cytotoxicity and hastens the progression of the tumor.21Therefore, a vital role is played by PD-1/PD-L1 pathway in the peripheral tolerance.22In addition, it mediates the inhibitory signals disclosing antitumor immunity. The gene discussed is CD274; the disease is neoplasm.