TNF and amyotrophic lateral sclerosis: 2009; Linkermann and Green 2014; Mifflin et al. 2020). Damage-associated molecular patterns (DAMPs) and the release of inflammatory factors are involved in the occurrence of many degenerative diseases of the central nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) (Re et al. 2014; Fischer and Maier 2015; Han et al. 2016). Several studies have confirmed that PTX can induce apoptosis of hippocampal neurons, accompanied by the release of inflammatory factors such as TNF-α and IL-1 β (Li et al. 2018).