RHO and intestinal cancer: Indeed, PI3K regulates cell migration by direct binding of the protein to its lipid products or indirectly via crosstalk with Rho GTPases.32 On the other hand, the Wnt/β-catenin pathway contributes to cell migration through E-cadherin redistribution, cytoskeleton rearrangement, and an increase in Rho family proteins.33 Additionally, synergism among mutations in the genes of both pathways during the development of intestinal cancers has previously been described promoting tumor aggressiveness in preclinical studies.34