A previous study showed that Wnt3a activates ROCK and directly phosphorylates GSK3β in a dependent form of the non-canonical Wnt pathway.37 Furthermore, our results showed that the PI3K inhibitor prevented the increase in proliferation and migration induced by the individual or combined treatment using Wnt3a and IGF, suggesting that these pathways cooperate during tumor progression. The gene discussed is PIK3CA; the disease is neoplasm.