The individual participation of the PI3K/Akt and Wnt/β-catenin pathways during the CRC progression is well established.13,14 However, recent studies have shown that an interaction between these two pathways contributes to the progression of various cancer types, including the ovary and pancreas.15,16 In CRC patient samples, the presence of nuclear β-catenin and an active PI3K/Akt pathway was associated with an increased risk of metastasis, suggesting a crosstalk between these pathways.17 However, little is known about how these pathways interact to contribute to CRC progression. The gene discussed is PIK3CA; the disease is colorectal carcinoma.