In addition, a large meta-analysis including over 12,000 patients showed that PIK3CA mutations were not significantly associated with CRC.5 On the other hand, mutations in APC seem to have a central impact on the survival of CRC patients.20 Furthermore, our data showed an association between mutations in the PI3K/Akt or Wnt/β-catenin pathway genes and colorectal cancer age of onset and early stages, suggesting that mutations in the genes of these pathways might be useful as prognostic predictive markers and/or as therapeutic targets to improve outcomes in CRC treatment. The gene discussed is APC; the disease is colorectal cancer.