We analyzed the presence of mutations in the main components of the Wnt/β-catenin (APC, CTNNB1, AXIN1 and AXIN2) and PI3K/Akt pathways (PI3KCA, PTEN, PIK3R1 and PIK3R2) in several open-access CRC clinical cohorts. This evidence concerns the gene PIK3R2 and colorectal carcinoma.