Thus, immunoPETE combines gDNA-based sequencing, used in other COVID-19 repertoire studies (15), with unique molecular identifier (UMI)-based deduplication of clonal expansions and correction of PCR sequencing errors; cell sorting to segregate functionally distinct CD4+ and CD8+ populations; human leukocyte antigen (HLA) typing to enhance clustering and determination of shared specificities within CD4+ and CD8+ T cell populations; and TRD sequencing permitting a real-time comparison of the responses of qualitatively distinct Vδ1 and Vδ2 subsets to a defined human virus infection. Here, CD8A is linked to viral infectious disease.