PGF and preeclampsia: Upregulated sFLT1 during preeclampsia is not an epiphenomenon; in our current animal model of UNx mice, which developed a preeclampsia-like state during late-term pregnancy, and in prior experimental models of preeclampsia in rats and baboons, neutralization of circulating sFLT1 with its natural antagonistic ligand PlGF or with RNA interference was effective in ameliorating the signs and symptoms of preeclampsia (18, 19).