We confirmed that known driver genes of prostate cancer were enriched for non-synonymous mutations, including TP53, RB1, PTEN, FOXA1, CDK12, AR, and SPOP among known Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census genes (dNdScv, q ≤ 0.1; Supplemental Table 1, C and D). This evidence concerns the gene SPOP and Familial prostate cancer.