TP53 and Familial prostate cancer: Certain prostate cancer driver genes were altered by multiple classes of structural alterations in both the gene body and flanking regions (e.g., AR, PTEN), while others were predominantly altered by a single alteration class (e.g., SNVs for TP53, intragenic translocations for TTC28, or flanking tandem duplications for MYC) (Figure 1C and Supplemental Figure 1C).