Certain prostate cancer driver genes were altered by multiple classes of structural alterations in both the gene body and flanking regions (e.g., AR, PTEN), while others were predominantly altered by a single alteration class (e.g., SNVs for TP53, intragenic translocations for TTC28, or flanking tandem duplications for MYC) (Figure 1C and Supplemental Figure 1C). Here, AR is linked to Familial prostate cancer.