TYK2 and Hepatic fibrosis: Ingenuity Pathway Analysis (IPA; QIAGEN) of SFRP2/DPP4 fibroblast gene expression with a focus on components that positively correlated with the mRSS revealed several prominent pathways: hepatic fibrosis/hepatic stellate cell activation, senescence, interferon signaling, sirtuin signaling, and TGF-β signaling, as well as several other pathways, including protein ubiquitination, oxidative phosphorylation, IL-1, IL-6, and role of JAK1, JAK2 and TYK2 in interferon signaling (JAK) (Figure 2A and Supplemental Table 5).