Furthermore, we observed that metabolic subtypes were significantly correlated with the frequency of copy number variation (CNVs) (Supplemental Figure 3, A–F) and gene mutations (Supplemental Figure 4, A–F) of several critical functional genes in NSCLC, including TP53, TTN, ZFHX4, CSMD3, SYNE1, and ROS1. The gene discussed is ZFHX4; the disease is non-small cell lung carcinoma.