Furthermore, we observed that metabolic subtypes were significantly correlated with the frequency of copy number variation (CNVs) (Supplemental Figure 3, A–F) and gene mutations (Supplemental Figure 4, A–F) of several critical functional genes in NSCLC, including TP53, TTN, ZFHX4, CSMD3, SYNE1, and ROS1. This evidence concerns the gene TP53 and non-small cell lung carcinoma.