Interestingly, our results indicate that statin significantly downregulated IFN-γ–induced mRNA and protein levels of PD-L1 in vitro (Supplemental Figure 10, A and B) and inhibited PD-L1 in mouse tumor tissues (Supplemental Figure 10C), suggesting that statin inhibited PD-L1 expression at the transcriptional level. Here, CD274 is linked to neoplasm.