For example, circ-ZKSCAN1, which was significantly dysregulated and reduced in expression in bladder cancer, was a potent molecular bio-marker, in addition, circ-ZKSCAN1 could further regulate the progression of bladder cancer by acting as a sponge for miR-1178 (Bi et al. 2019); circ_0008305 had decreased expression in lung cancer and could also act as a sponge for miR-429 and miR-200b to further regulate lung cancer progression (Wang et al. 2018). Here, ZKSCAN1 is linked to urinary bladder cancer.