LGALS1 and HIV-1 infection: Notably, previous work has shown that Gal-1 (but not Gal-3) can facilitate HIV-1 infection in monocyte-derived macrophages by sustaining early events of the virus replicative cycle, including adsorption and entry (77), indicating that Gal-1 could influence viral infection by modulating both the T cell and macrophage compartments.